DETERMINAÇÃO ESPECTROFOTOMÉTRICA DE DICLOFENACO DE SÓDIO EM FORMULAÇÃO FARMACÊUTICA EMPREGANDO O CONCEITO DE FIA-MULTICOMUTAÇÃO

Abstract

International and national bodies require the development of analytical methods that are rapid, inexpensive and accurate for the determination of drugs. One way to meet these requirements a method of flow injection analysis employing multicommutation and spectrophotometric detection was used. In this paper an automated system was developed to determine diclofenac sodium in injectables. The reaction is based on the oxidation of diclofenac sodium with potassium permanganate in acid medium be-ing monitored at 465 nm this. The calibration curve was linear over the concentration range of 20-80 mg Lˉ¹ with a detection limit of 0.1 mg Lˉ¹ standard deviation of 0.9% (n = 20) and Sample Rate 80 samples per hour. The proposed method was applied successfully in three injectable solutions and the samples were compared with the official method and other automated methods employing the same reaction.