PROGRAMA DE PÓS-GRADUAÇÃO EM SAÚDE MATERNO-INFANTIL - PPG Saúde Materno Infantil

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Navegando PROGRAMA DE PÓS-GRADUAÇÃO EM SAÚDE MATERNO-INFANTIL - PPG Saúde Materno Infantil por Assunto "CNPQ::CIENCIAS DA SAUDE::MEDICINA"

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    ANÁLISE DA EXPRESSÃO DOS RECEPTORES DA SOMATOSTATINA (SST1-5) E DA DOPAMINA (DR2) EM ADENOMAS HIPOFISÁRIOS
    (Universidade Federal do Maranhão, 2012-03-12) Nunes, Bruno de Almeida; Faria, Manuel dos Santos; CPF:33207194753; MESQUITA, Emygdia Rosa do Rego Barros Pires Leal; CPF:33301018300; http://lattes.cnpq.br/0374728351065012
    Pituitary tumors represent 15% of intracranial neoplasms and are usually benign. The treatment primary is surgical resection with exception for prolactinomas because dopamine agonists are very effective in the treatment these tumors. If surgery does not lead to healing, it is necessary other therapeutic strategy in a attempt to control hormone levels and tumor size reduction. The radiotherapy and medical treatment with somatostatin analogs and agonist dopamine are often used. The study aimed to analyze the presence, distribution and frequency of somatostatin receptor and dopamine receptor (DR2) in pituitary adenomas, and compared their mRNA expression and protein expression. We studied 38 patients with pituitary adenomas. The GH-secreting adenomas showed immunoreactivity more frequent SST2 and SST3 present in 100% of the tumors followed SST5, SST4 and SST1 respectively. Clinically nonfunctioning adenomas SST3 receptor was most widely distributed, present in 13 of 14 tumors followed SST2, SST4, SST1 and SST5 respectively. The mRNA expression of SST2 and SST5 receptor was present in all pituitary adenomas with higher expression of SST2. The DR2 receptor was present and 85% of samples analyzed. In conclusion, the high expression of SST2 in somatotropinomas support the possibility of the use of octreotide as an adjunct therapy in the treatment of acromegalic patients. Patients with clinically nonfunctioning adenomas showed expression of somatostatin receptor and dopamine which indicates the possibility of treating these patients with the somatostatin analogues and / or dopamine agonists.
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    PRODUTO DA ACUMULAÇÃO LIPÍDICA NA DETECÇÃO DE FATORES DE RISCO PARA DOENÇAS CARDIOVASCULARES EM MULHERES COM SÍNDROME DOS OVÁRIOS POLICÍSTICOS
    (Universidade Federal do Maranhão, 2012-10-29) Nascimento, Joelma Ximenes Prado Teixeira; CHEIN, Maria Bethânia da Costa; CPF:71725431734; http://lattes.cnpq.br/6140088004101694; Figueiredo Neto, José Albuquerque de; CPF:37407350400; http://lattes.cnpq.br/4599029240915353
    The polycystic ovary syndrome (PCOS) is considered the most common endocrine disease during the woman's reproductive life, with prevalence ranging from 5 to 10% of women of reproductive age and is characterized by chronic anovulation and hyperandrogenism, showing complex multifactorial pathogenesis. Objective: To determine the cutoff the lipid accumulation product in women with polycystic ovary syndrome. Methods: Cross-sectional study with 78 women between 18 and 42 years diagnosed with polycystic ovary syndrome according to the Rotterdam criteria directed to nutritional evaluation at the Maternal and Child Unit of the University Hospital UFMA. The interest variables were recorded in protocol form: socio-demographic, behavioral, gynecological history, personal and family history of diseases, anthropometric data (weight, height, body mass index and waist circumference), laboratory tests, imaging exams and blood pressure values. The product of lipid accumulation was calculated by the formula described by Kahn. Regarding the analysis of data normality of quantitative variables was analyzed by the Shapiro Wilk; to compare the means of the variables we used the t Student test. To check the correlation between the lipid product accumulation and cardiovascular risk markers was applied Linear Correlation coefficient (r) test. The lipid product accumulation was analyzed according to the Receiver Operating Characteristic Curve, being discriminated values of high sensitivity and specificity simultaneously. The significance level for all tests was 5%. Results: Using the Receiver Operating Characteristic curve to determine the best cutoff of predicted LAP index risk for cardiovascular disease, it was noted that the value above 39.32 cm.mmol/L representing the area under the 0.8845 of the curve. Every women who had lipid product accumulation product value above the cutoff defined also showed the highest changes in mean of risk markers analyzed of cardiovascular diseases, a statistically significant difference. Regarding the analysis of correlation between the product of lipid accumulation above the cutoff defined and risk markers for cardiovascular diseases, there was a significant correlation. Conclusion: These results demonstrate that cutoff values ≥ 39.32 cm.mmol/L of LAP index seems to indicate the increased risk for CVD and should be used as a screening tool and research for its ease of measurement and interpretation, as well as its low cost and may even have its applicability in primary health care.