DISSERTAÇÃO DE MESTRADO - PROGRAMA DE PÓS-GRADUAÇÃO EM QUIMICA

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Detecção fotoeletroanalítica de adrenalina baseada em DNA e nanopartículas de TiO2 sensibilizadas com Bis (Etilenoditio) tetratiofulvaleno explorando luz de led
(Universidade Federal do Maranhão, 2017-09-11) SANTOS, Thiago Augusto Dias; DAMOS, Flávio Santos; 846.255.703-87; http://lattes.cnpq.br/0915687070195770; ARAUJO, Adriana Barbosa; http://lattes.cnpq.br/1008844766307732; SANTANA, Sirlane Aparecida Abreu; http://lattes.cnpq.br/1052349578152491
A photoelectroanalytical sensor was developed, based on deoxyribonucleic acid (DNA) and anatase titanium dioxide (TiO2) nanoparticles sensitized with bis(ethylenedithio)tetrathiofulvalene (BEDT-TTF) for determination of the adrenaline, also denominated as epinephrine. The photosensor composite developed was denominated as BEDT-TTF/DNA/TiO2/ITO and shows a high photocurrent for the adrenaline under light emitting diode (LED) irradiation in comparison to each component of the composite material. Under optimized conditions, the BEDTTTF/DNA/TiO2/ITO sensor shows a linear response range from 10 nmol L-1 up to 100 μmol L-1 with a sensitivity of 8,1 nA L μmol-1 and limit of detection of 1 nmol L-1 for the adrenaline. The photoelectrochemical sensor showed high photocurrent to adrenaline in comparison to photocurrent response to ascorbic acid and uric acid. The BEDT-TTF/DNA/TiO2/ITO photoelectrochemical sensor was successfully applied to urine samples, with recovery values between 96 and 106%.